Open AccessHLA-G Level on Monocytoid Dendritic Cells Correlates With Regulatory T-Cell Foxp3 Expression in Liver Transplant Tolerance
Author(s) -
Antonino Castellaneta,
George Mazariegos,
Navdeep Nayyar,
Adriana Zeevi,
Angus W. Thomson
Publication year - 2011
Publication title -
transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.45
H-Index - 204
eISSN - 1534-6080
pISSN - 0041-1337
DOI - 10.1097/tp.0b013e31821414c9
Subject(s) - foxp3 , immunology , dendritic cell , human leukocyte antigen , biology , flow cytometry , antibody , t cell , immune system , antigen
Human leukocyte antigen (HLA)-G is a nonclassical HLA class I molecule expressed as membrane-bound and soluble isoforms. Interaction of HLA-G with its receptor, immunoglobulin-like transcript 4 on dendritic cells (DCs) down-regulates their T-cell stimulatory ability.