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Hepatitis C virus (HCV) core and nonstructural (NS) 3 proteins induce inflammation and immunity through a toll-like receptor (TLR) 2-dependent pathway. Individuals with the R753Q single-nucleotide polymorphism (SNP) in the TLR2 gene have increased the risk of allograft failure after liver transplantation for chronic hepatitis C.

R753Q Single-Nucleotide Polymorphism Impairs Toll-Like Receptor 2 Recognition of Hepatitis C Virus Core and Nonstructural 3 Proteins