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The decision to use induction antibody therapy in kidney transplantation is often based on perceived patient risk, as no objective biomarker has been shown to predict the effectiveness of such therapy. Because pretransplant T-cell alloreactivity has been shown to increase the risk of poor posttransplant outcome, and because induction therapy is directed at alloreactive T cells, we hypothesized that antibody induction would preferentially benefit patients with high pretransplant antidonor T-cell immunity.

transplantation

Preferential Benefit of Antibody Induction Therapy in Kidney Recipients With High Pretransplant Frequencies of Donor-Reactive Interferon-γ Enzyme-Linked Immunosorbent Spots