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Lysyl oxidase-like 1 knockout (Loxl1) mice demonstrate deficient elastin homeostasis associated with pelvic organ prolapse (POP). To further investigate the pathophysiology of POP in these animals, a genetically matched homozygous positive (Loxl1) or wild-type strain is needed. This study sought to create and validate genetically matched Loxl1 and Loxl1 strains.

Validation of Genetically Matched Wild-Type Strain and Lysyl Oxidase–Like 1 Knockout Mouse Model of Pelvic Organ Prolapse