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Simian immunodeficiency virus (SIV) infection in macaques chronically receiving ethanol results in significantly higher plasma viral loads and more rapid progression to end-stage disease. We thus hypothesized that the increased plasma viral load in ethanol-treated, SIV-infected macaques would negatively correlate with antigen-specific immune responses.

Effects of Alcohol Consumption on Antigen-Specific Cellular and Humoral Immune Responses to SIV in Rhesus Macaques