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Title: Isolated Hepatitis B Core Antibody is Associated with Advanced Hepatic Fibrosis in HIV/HCV Infection but not in HIV infection alone Authors and Affiliations: Debika Bhattacharya MD, MS 1,2 , Chi-hong Tseng PhD 2 , Janet P. Tate ScD 3,4 , Vincent Lo Re III MD, MSCE 5,6 , Cynthia L. Gibert MD 7,8 , Adeel A. Butt MD 9,10 , Sheldon T. Brown MD 11,12 , Joseph K. Lim MD 3,4 , Maria C. Rodriguez-Barradas MD 13,14 , David Rimland MD 15,16 , Erica Kaufman MD 17 , Amy C. Justice MD, PhD 3,4 , Matthew Bidwell Goetz MD 1,2 1. VA Greater Los Angeles Healthcare System, Los Angeles, CA, USA, 2. David Geffen School of Medicine at UCLA, Los Angeles, CA, USA, 3. VA Connecticut Healthcare System, West Haven, CT, USA, 4. Yale University School of Medicine, New Haven, CT, USA, 5. Philadelphia VA Medical Center, Philadelphia, PA, USA, 6. Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA, 7. Washington DC VA Medical Center, Washington, DC, USA, 8. George Washington University Medical Center, Washington, DC, USA, 9. Hamad Healthcare Quality Institute and Hamad Medical Corporation, Doha, Qatar, 10. VA Pittsburgh Healthcare System, Pittsburgh, PA, USA, 11. James J. Peters VA Medical Center, Bronx, NY, USA, 12. Icahn School of Medicine at Mt. Sinai, New York, NY, USA, 13. Michael E. DeBakey VA Medical Center, Houston, TX, USA, 14. Baylor College of Medicine, Houston, TX, USA, 15. Atlanta VA Medical Center, Atlanta, GA, USA, 16. Emory University School of Medicine, Atlanta, GA, USA, 17. Saint Louis University School of Medicine, Saint Louis, MO, USA Keywords: Hepatitis B Core Antibody, HIV, hepatitis C Running Head: Isolated HBcAb and Hepatic Fibrosis 40 Word Summary: HIV+/HCV+ persons with isolated HBcAb have a higher prevalence of advanced fibrosis than persons who are non-immune to HBV, who have resolved HBV, or who are HbsAb+ only. Corresponding Author: Debika Bhattacharya MD MS Associate Clinical Professor of Medicine Division of Infectious Diseases and UCLA CARE Center David Geffen School of Medicine at the University of California, Los Angeles VA Greater Los Angeles Healthcare System 11301 Wilshire Blvd 111F Los Angeles, CA 90073

Isolated Hepatitis B Core Antibody is Associated With Advanced Hepatic Fibrosis in HIV/HCV Infection But Not in HIV Infection Alone