Open AccessPlatelet count kinetics following interruption of antiretroviral treatment
Author(s) -
Eva Zetterberg,
Jacqueline Neuhaus,
Jason V. Baker,
Charurut Somboonwit,
Josep M. Llibre,
Adrian Palfreeman,
Maria Chini,
Jens D. Lundgren
Publication year - 2013
Publication title -
aids
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.195
H-Index - 216
eISSN - 1473-5571
pISSN - 0269-9370
DOI - 10.1097/qad.0b013e32835a104d
Subject(s) - medicine , kinetics , platelet , antiretroviral therapy , human immunodeficiency virus (hiv) , virology , immunology , viral load , physics , quantum mechanics
To investigate the mechanisms of platelet kinetics in the Strategies for Management of Antiretroviral Therapy (SMART) study that demonstrated excess mortality with CD4 guided episodic antiretroviral therapy (ART) drug conservation compared with continuous treatment viral suppression. Follow-up analyses of stored plasma samples demonstrated increased activation of both inflammatory and coagulation pathways after stopping ART.