Open AccessEpigenetic regulation of telomerase expression in HIV-1-specific CD8+ T cells
Author(s) -
Katie Williams,
Katherine Seiss,
Jill Beamon,
Florencia Pereyra,
Eric Rosenberg,
Bruce D. Walker,
Xu G. Yu,
Mathias Lichterfeld
Publication year - 2010
Publication title -
aids
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.195
H-Index - 216
eISSN - 1473-5571
pISSN - 0269-9370
DOI - 10.1097/qad.0b013e32833c7170
Subject(s) - telomerase , cytotoxic t cell , epigenetics , telomerase reverse transcriptase , biology , dna methylation , cd8 , telomere , methylation , cancer research , microbiology and biotechnology , gene expression , immunology , genetics , gene , antigen , in vitro
Telomerase activity in HIV-1-specific CD8(+) T cells from controllers contributes to the maintenance of highly functional cytotoxic T cell responses against HIV-1. Here, we show that high expression of telomerase in controllers is associated with hypermethylation at the distal and hypomethylation at the proximal human telomerase catalytic subunit promoter, whereas HIV-1-specific CD8(+) T cells from progressors showed an inverse pattern with distal promoter hypomethylation and proximal promoter hypermethylation. These data suggest distinct epigenetic signatures in HIV-1-specific T cells in progressors and controllers.