Open AccessIncreased aldosterone among HIV-infected women with visceral fat accumulation
Author(s) -
Janet Lo,
Sara E. Looby,
Jiann-Wu Wei,
Gail K. Adler,
Steven Grinspoon
Publication year - 2009
Publication title -
aids
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.195
H-Index - 216
eISSN - 1473-5571
pISSN - 0269-9370
DOI - 10.1097/qad.0b013e3283328d3b
Subject(s) - aldosterone , medicine , endocrinology , adipose tissue , blood pressure , urine , obesity , metabolic syndrome , human immunodeficiency virus (hiv) , immunology
Increased aldosterone has been associated with obesity and the metabolic syndrome in non-HIV-infected individuals, but aldosterone has not been investigated among HIV-infected patients with increased visceral adipose tissue (VAT). Twenty-four-hour urine aldosterone was assessed among age and BMI-matched HIV-infected women with increased VAT, HIV-infected women without increased VAT and healthy controls. Twenty-four hour urine aldosterone was higher in HIV-infected women with increased VAT and was associated with SBP, VAT and hemoglobin A1c. Increased aldosterone may contribute to the detrimental effects of excess visceral adiposity on blood pressure and glucose homeostasis among HIV patients.