Open AccessKupffer cells are depleted with HIV immunodeficiency and partially recovered with antiretroviral immune reconstitution
Author(s) -
Ashwin Balagopal,
Stuart C. Ray,
Ruben Montes de,
Catherine G. Sutcliffe,
Perumal Vivekanandan,
Yvonne Higgins,
Shruti H. Mehta,
Richard D. Moore,
Mark S. Sulkowski,
David L. Thomas,
Michael Torbenson
Publication year - 2009
Publication title -
aids
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.195
H-Index - 216
eISSN - 1473-5571
pISSN - 0269-9370
DOI - 10.1097/qad.0b013e3283324344
Subject(s) - kupffer cell , lymphocyte , liver biopsy , medicine , fibrosis , immunology , immune system , pathology , hepatitis , immunopathology , liver disease , viral disease , biopsy , gastroenterology , human immunodeficiency virus (hiv)
HIV-related enhancement of gut microbial translocation is associated with progression of hepatic fibrosis. Although hepatic macrophages (Kupffer cells) clear most microbial translocation products and can be infected by HIV, their fate in HIV progression has not been carefully investigated.