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Depressive symptoms and the apolipoprotein E (APOE) ε4 allele are independent risk factors for cognitive decline. However, it is not clear whether the presence of both depressive symptoms and the APOE ε4 allele increases cognitive decline.

Gene-Behavior Interaction of Depressive Symptoms and the Apolipoprotein E [Latin Small Letter Open E]4 Allele on Cognitive Decline