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Studies have demonstrated that human adipose-derived stromal cells (ASCs) are able to repair acute calvarial injuries. The more clinically relevant repair of an established skeletal defect, however, has not been addressed. The authors sought to determine whether human ASCs could heal chronic (established) calvarial defects.

Acute Skeletal Injury Is Necessary for Human Adipose-Derived Stromal Cell–Mediated Calvarial Regeneration