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The sonic hedgehog (Shh) pathway has an established role in pancreatic cancer (pancreatic adenocarcinoma [PDAC]). We tested whether magnetic resonance imaging measures of vascular volume fraction (VVF) using magnetic iron oxide nanoparticles are sensitive to the antiangiogenic effect of targeted Shh therapies in a PDAC xenograft model.

Magnetic Resonance Imaging Monitors Physiological Changes With Antihedgehog Therapy in Pancreatic Adenocarcinoma Xenograft Model