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A functional vacuolar adenosine triphosphatase (v-ATPase) complex regulates canonical Wnt/β-catenin signaling. The goal of this study was to identify the distribution of the v-ATPase in human and murine models of pancreatic intraepithelial neoplasms (PanINs) and assess its role in Wnt/β-catenin signaling.

Polarization of the Vacuolar Adenosine Triphosphatase Delineates a Transition to High-Grade Pancreatic Intraepithelial Neoplasm Lesions