Open AccessClonal Expansions and Short Telomeres Are Associated with Neoplasia in Early-onset, but not Late-onset, Ulcerative Colitis
Author(s) -
Jesse J. Salk,
Aasthaa Bansal,
Lisa A. Lai,
David A. Crispin,
Cigdem Ussakli,
Marshall S. Horwitz,
Mary P. Bronner,
Teresa A. Brentnall,
Lawrence A. Loeb,
Peter S. Rabinovitch,
Rosa Ana Risques
Publication year - 2013
Publication title -
inflammatory bowel diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.932
H-Index - 146
eISSN - 1536-4844
pISSN - 1078-0998
DOI - 10.1097/mib.0b013e3182a87640
Subject(s) - ulcerative colitis , telomere , colorectal cancer , medicine , colitis , gastroenterology , age of onset , cancer , biology , disease , genetics , gene
Patients with ulcerative colitis (UC) are at risk of developing colorectal cancer. We have previously reported that cancer progression is associated with the presence of clonal expansions and shorter telomeres in nondysplastic mucosa. We sought to validate these findings in an independent case-control study.
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