Open AccessHuman β-Defensin 3 Peptide Is Increased and Redistributed in Crohn’s Ileitis
Author(s) -
Jeffrey P. Meisch,
Michiko Nishimura,
Ryan M. Vogel,
Hannah C. Sung,
Beth Bednarchik,
Santosh K. Ghosh,
Pingfu Fu,
Thomas S. McCormick,
Aaron Weinberg,
Alan D. Levine
Publication year - 2013
Publication title -
inflammatory bowel diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.932
H-Index - 146
eISSN - 1536-4844
pISSN - 1078-0998
DOI - 10.1097/mib.0b013e318280b11a
Subject(s) - paneth cell , defensin , lamina propria , antimicrobial peptides , peptide , ileitis , beta defensin , biology , ileum , microbiology and biotechnology , gastrointestinal tract , epithelium , immunology , crohn's disease , pathology , medicine , small intestine , biochemistry , disease , genetics
Antimicrobial peptides (AMPs) maintain a sterile environment in intestinal crypts, limiting microbial colonization and invasion. Decreased AMP expression is proposed to increase the risk for inflammatory bowel disease. Expression and function of inducible AMPs, human β-defensin 2 and 3 (hBD-2 and hBD-3), remain poorly characterized in healthy and chronically inflamed intestine.
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