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NUDT15 c.415C&gt;T was a novel genetic marker confirmed in our center for thiopurine-induced leukopenia in Chinese inflammatory bowel disease (IBD). For validation, a large cohort study is needed. Meanwhile, the newly discovered NUDT15 coding variants (c.36_37insGGAGTC and c.52 G&gt;A) have not been studied in patients with IBD. We aimed to further confirm the influence of 3 NUDT15 variants (c.415C&gt;T, c.36_37insGGAGTC, and c.52G&gt;A) on thiopurine-induced leukopenia in Chinese patients with IBD.

Combined Detection of NUDT15 Variants Could Highly Predict Thiopurine-induced Leukopenia in Chinese Patients with Inflammatory Bowel Disease