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Helminth-derived molecules are being identified as a new therapeutic approach for immune-mediated diseases. We investigated the anti-inflammatory effect and the immunological mechanisms of Schistosoma mansoni soluble egg antigens (SmSEA) in a mouse model of chronic colitis.

Treatment with Egg Antigens of Schistosoma mansoni Ameliorates Experimental Colitis in Mice Through a Colonic T-cell–dependent Mechanism