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Neurological side effects of MTX are uncommon. In literature no previous case of MTX induced paraparesis in patients treated with low-dose MTX for chronic arthritis has been described. The association between the gene polymorphisms of MTHFR (c.1298A>C and c.677C>T) and MTX toxicity in arthritis patients is confirmed. The case also confirms that folates are a precious antidote of MTX toxicity.

medicine

Complete clinical and functional recovery following low-dose methotrexate related paraparesis in a patient with compound c.1298A&gt;C AND c.677C&gt;T MTHFR polymorphism