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Rationale:  Colonic lipomas are uncommon benign submucosal adipose tumorsthat are usually asymptomatic. Large lipomas can cause symptoms require treatment in principle. We report 1 case of giant colonic lipoma removed with endoloop-assisted unroofing technique instead of conventional surgical bowel resection.    Patient concerns:  A 62-year-old female patient presented with intermittent abdominal discomfort for 1 month.    Diagnosis:  The patient was diagnosed as having a giant colonic lipoma.    Intervention:  Endoscopic resection with endoloop-assisted unroofing technique was performed. On the 22nd day after resection, intestinal obstruction occurred by shedding mass was found; the symptoms of this patient disappeared soon after removal of the mass by endoscopy.    Outcomes:  A follow-up colonoscopy 6 months later showed a scarred mucosa at the ligation site and no residual lipoma was observed.    Lessons:  Endoscopic resection with endoloop-assisted unroofing technique remains a viable option for giant lipomas; however, postoperative intestinal obstruction caused by shedding mass should be noted.

Endoscopic resection of a giant colonic lipoma with endoloop-assisted unroofing technique