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Our study provided evidence that hyperhomocysteinemia (HHcy) and MTHFR C677T polymorphism were associated with IS. More importantly, suggesting that a possible synergistic effect of MTHFR C677T polymorphism on Hcy level variations increased risk for IS in Chinese population.

A possible synergistic effect of MTHFR C677T polymorphism on homocysteine level variations increased risk for ischemic stroke