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Objective:To investigate the relationship between excision repair cross-complementing group 1 (ERCC1)-4533/8092, tumor necrosis factor-alpha (TNF-&agr;)-238/308 polymorphisms, and the risk of hepatocellular carcinoma (HCC) in Guangxi Zhuang population of China. Methods:Polymerase chain reaction-restriction fragment length polymorphism method was used to detect the ERCC1-4533/8092 and TNF-&agr;-238/308 polymorphisms in 88 cases with HCC and 82 cases of normal control. Results:There were no differences in the frequency distribution of ERCC1-4533 and TNF-&agr;-238 polymorphisms in the HCC group and the control group (P > 0.05). The genotype frequency distributions of the ERCC1-8092 and TNF-&agr;-308 in the HCC group and the control group were different (P < 0.05). Compared with ERCC1-8092 CC genotype, ERCC1-C8092 CA/AA genotype had higher risk of HCC (CA/AA vs CC; odds ratio 3.51, 95% confidence interval 1.03–12.016). Compared with TNF-&agr;-308 GG genotype, TNF-&agr;-308 GA/AA genotype was significantly associated with an increased risk of HCC (GA/AA vs GG; odds ratio 3.84, 95% confidence interval 1.011–14.57). Conclusion:The genetic polymorphisms of ERCC1-8092 and TNF-&agr;-308 are associated with the risk of HCC in Guangxi Zhuang population of China.

The ERCC1-4533/8092, TNF-α 238/308 polymorphisms and the risk of hepatocellular carcinoma in Guangxi Zhuang populations of China