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Background:  Antibiotic resistance continues to rise due to the increased number of antibiotic prescriptions and is now a major threat to public health. In particular, there is an increase in antibiotic resistance to  Escherichia coli  according to the latest reports.    Trial Design:  This article examines, retrospectively, antibiotic resistance in patients with community- and nosocomial-acquired pneumonia caused by  E coli.Methods:  The data of all patients with community- and nosocomial-acquired pneumonia caused by  E coli  were collected from the hospital charts at the HELIOS Clinic, Witten/Herdecke University, Wuppertal, Germany, within the study period 2004 to 2014. An antibiogram was performed for the study patients with pneumonia caused by  E coli . Antimicrobial susceptibility testing was performed for the different antibiotics that have been consistently used in the treatment of patients with pneumonia caused by  E coli.  All demographic, clinical, and laboratory data of all of the patients with pneumonia caused by  E coli  were collected from the patients’ records.    Results:  During the study period of January 1, 2004 to August 12, 2014, 135 patients were identified with community- and nosocomial-acquired pneumonia affected by  E coli . These patients had a mean age of 72.5 ± 11.6 (92 [68.1%, 95% CI 60.2%–76.0%] males and 43 [31.9%, 95% CI 24.0%–39.8%] females).  E coli  had a high resistance rate to ampicillin (60.7%), piperacillin (56.3%), ampicillin–sulbactam (44.4%), and co-trimoxazole (25.9%). No patients with pneumonia caused by  E coli  showed resistance to imipenem ( P  < 0.0001).    Conclusion:   E coli  was resistant to many of the typically used antibiotics. No resistance was detected toward imipenem in patients with pneumonia caused by  E coli .

No Development of Imipenem Resistance in Pneumonia Caused by Escherichia coli