Open AccessSarcoplasmic Reticulum-Mitochondrial Symbiosis
Author(s) -
Ann E. Rossi,
Simona Boncompagni,
Robert T. Dirksen
Publication year - 2008
Publication title -
exercise and sport sciences reviews
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 1.945
H-Index - 99
eISSN - 1538-3008
pISSN - 0091-6331
DOI - 10.1097/jes.0b013e3181911fa4
Subject(s) - endoplasmic reticulum , microbiology and biotechnology , mitochondrion , adenosine triphosphate , organelle , calcium signaling , skeletal muscle , calcium , chemistry , biology , biochemistry , signal transduction , endocrinology , organic chemistry
In mammalian skeletal muscle, an intimate association between the sarcoplasmic reticulum (SR) and mitochondria results in a symbiotic and privileged bidirectional communication between these organelles. Orthograde signaling reflects SR calcium (Ca) release stimulating mitochondrial adenosine triphosphate production via excitation-metabolism coupling. Retrograde signaling involves mitochondrial inhibition of local SR Ca release by controlling the redox environment of the Ca release unit.
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