Open AccessVaccine-derived Human-bovine Double Reassortant Rotavirus in Infants With Acute Gastroenteritis
Author(s) -
Maria Hemming,
Timo Vesikari
Publication year - 2012
Publication title -
the pediatric infectious disease journal/the pediatric infectious disease journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.028
H-Index - 140
eISSN - 1532-0987
pISSN - 0891-3668
DOI - 10.1097/inf.0b013e31825d611e
Subject(s) - medicine , rotavirus , virology , acute gastroenteritis , reoviridae , rotavirus vaccine , vaccination , diarrhea , virus , pediatrics
We describe 3 cases of acute gastroenteritis in healthy infants after vaccination with RotaTeq, shedding a G1P[8] human-bovine double reassortant rotavirus in stools. Such a double reassortant virus appears stable in vitro and may explain diarrheal symptoms in a small percentage of RotaTeq recipients, and might also be transmitted to contacts in the environment.