Open AccessCardiac Myosin Epitopes for Monitoring Progression of Rheumatic Fever
Author(s) -
Davina Gorton,
Brenda Govan,
Natkunam Ketheesan,
Alan Sive,
Robert Norton,
Bart J. Currie,
Rebecca J. Towers,
Adita Mascaro-Blanco,
Madeleine W. Cunningham
Publication year - 2011
Publication title -
the pediatric infectious disease journal/the pediatric infectious disease journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.028
H-Index - 140
eISSN - 1532-0987
pISSN - 0891-3668
DOI - 10.1097/inf.0b013e31823058dd
Subject(s) - rheumatic fever , medicine , carditis , epitope , antibody , heart disease , immunology , acute rheumatic fever , streptococcus , biology , bacteria , genetics
[Extract] Rheumatic fever (RF) and rheumatic heart disease (RHO) have become rare in the developed world, but remain major causes of childhood diseases in developing countries and in some indigenous communities. In populations endemic for RF/RHD, additional factors other than those currently included in the Revised Jones Criteria would increase diagnostic sensitivity. Moreover, identification of robust markers for disease activity could provide better monitoring and delivery of health care for patients