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After introduction of the 7-valent pneumococcal conjugate vaccine (PCV7) in the United States in 2000, emergence of replacement serotypes occurred, leading to the introduction of a 13-valent pneumococcal conjugate vaccine (PCV13) in 2010 that contained all PCV7 serotypes plus 6 additional serotypes (1, 3, 5, 6A, 7F and 19A). Here, we describe a 9-year prospective, longitudinal study characterizing Streptococcus pneumoniae strains colonizing the nasopharynx (NP) of young children based on serotype, sequence type (ST) and antibiotic susceptibility during the PCV7 and PCV13 eras.

the pediatric infectious disease journal/the pediatric infectious disease journal

Emerging Streptococcus pneumoniae Strains Colonizing the Nasopharynx in Children After 13-valent Pneumococcal Conjugate Vaccination in Comparison to the 7-valent Era, 2006–2015