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Strong associations exist between tumor necrosis factor-α (TNF-α) and metabolic syndrome (MetS). Although TNF-α is associated with bipolar depression (BD), its role in atypical antipsychotic (AAP)-associated MetS in BD is unclear. Here, we investigate the potential intervening role of TNF-α in the indirect relationship between AAP treatment and MetS in BD.

therapeutic drug monitoring

A Pilot Study Investigating Tumor Necrosis Factor-α as a Potential Intervening Variable of Atypical Antipsychotic–Associated Metabolic Syndrome in Bipolar Disorder