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To identify the mechanisms underlying the decreased allelic expression of a common CYP2A13 allele (7520C&gt;G) in the human lung; CYP2A13 is expressed selectively in the respiratory tract, and is highly efficient in the metabolic activation of several chemical carcinogens.

pharmacogenetics and genomics

Mechanisms of differential expression of the CYP2A13 7520C and 7520G alleles in human lung: allelic expression analysis for CYP2A13 heterogeneous nuclear RNA, and evidence for the involvement of multiple Cis-regulatory single nucleotide polymorphisms