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Seeking a model of spontaneous metastatic melanoma, we imported the Hgf-Cdk4R24C mouse line in which overexpression of hepatocyte growth factor (Hgf) promotes melanocyte proliferation and migration and the clinically relevant mutation in cyclin-dependent kinase 4 (Cdk4R24C) prevents binding to the t

Widespread spontaneous hyperproliferation, melanosis and melanoma in Hgf-Cdk4 R24C mice