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To the Editor: In December 2019, coronavirus disease released 2019-nCoV sequences. Among all the observed 2019 outbreak caused by the 2019 novel coronavirus variation sites, three (positions on the reference genome (2019-nCoV) happened in Wuhan, China. Now, it has posed a worldwide public health threat. Real-time quantitative polymerase chain reaction (RT-qPCR) was recommended as an effective pathogen detection method and has played an important role in prevention and control of the current outbreak. Many research institutions have released their primer sets for RT-qPCR. If the variant sites were located in the primer regions, the efficiency of RT-qPCR would be reduced, thus possibly causing false negative results, and leading tounpredictable impact on thediagnosis of patients and the control of this outbreak. Therefore, a comprehensive investigation on 2019-nCoV genome variation is necessary to evaluate the effectiveness of current released RT-qPCR methods.

chinese medical journal/chinese medical journal

In silico assessment of the impact of 2019 novel coronavirus genomic variation on the efficiency of published real-time quantitative polymerase chain reaction detection assays