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The intestinal microbiota consists of trillions of microliver. Furthermore, bacterially-derived metabolites may organisms, most of which are considered to be nondirectly modulate the expression of hepatic cytochrome pathogenic and play a defensive role in host immune system. Imbalance of the bacterial community has been associated with multiple host diseases, including fatty liver, metabolic syndromes, inflammatory bowel disease, and colon cancer. The liver is connected with the gut at both anatomical and physiological levels, and exposed to the products of the gut microbiota through the portal vein. Thus liver pathophysiology is closely influenced by the gut microbiota.

Gut microbiota and drug-induced liver injury: an update