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Plasma interleukin-8 levels of &lt;220 pg/mL have an excellent negative predictive value (94% to 95%) for death at 28 days in children with septic shock and thus may be useful for risk stratification in clinical trial enrollment in this population. Whether plasma interleukin-8 would have similar utility in adults with septic shock is unknown.

Plasma interleukin-8 is not an effective risk stratification tool for adults with vasopressor-dependent septic shock*