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Scleroderma and other autoimmune-induced connective tissue diseases are characterized by dysfunctions in the immune system, connective tissue and the vasculature. We are focusing on systemic sclerosis (SSc)-associated pulmonary hypertension, which remains a leading cause of death with only a 50-60% of 2-year survival rate.

current opinion in rheumatology/current opinion in rheumatology, with evaluated medline

Aberrant immune response with consequent vascular and connective tissue remodeling – causal to scleroderma and associated syndromes such as Raynaud phenomenon and other fibrosing syndromes?