Open AccessEffect of Hyperoxia on Resuscitation of Experimental Combined Traumatic Brain Injury and Hemorrhagic Shock in Mice
Author(s) -
Brian Blasiole,
Hülya Bayır,
Vincent A. Vagni,
Keri JaneskoFeldman,
Amin Cheikhi,
Stephen R. Wisniewski,
Joseph B. Long,
James L. Atkins,
Valerian E. Kagan,
Patrick M. Kochanek
Publication year - 2013
Publication title -
anesthesiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.874
H-Index - 234
eISSN - 1528-1175
pISSN - 0003-3022
DOI - 10.1097/aln.0b013e318280a42d
Subject(s) - medicine , hyperoxia , resuscitation , anesthesia , neuroinflammation , shock (circulatory) , oxygen tension , inflammation , oxygen , lung , chemistry , organic chemistry
Hypotension and hypoxemia worsen traumatic brain injury outcomes. Hyperoxic resuscitation is controversial. The authors proposed that hyperoxia would improve hemodynamics and neuronal survival by augmenting oxygen delivery despite increased oxidative stress and neuroinflammation in experimental combined controlled cortical impact plus hemorrhagic shock in mice.
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