Open AccessDrosophila Ryanodine Receptors Mediate General Anesthesia by Halothane
Author(s) -
Shuying Gao,
David J. Sandstrom,
Harold E. Smith,
Brigit High,
Jon W. Marsh,
Howard A. Nash
Publication year - 2012
Publication title -
anesthesiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.874
H-Index - 234
eISSN - 1528-1175
pISSN - 0003-3022
DOI - 10.1097/aln.0b013e31827e52c6
Subject(s) - halothane , ryanodine receptor , microbiology and biotechnology , anesthetic , electrophysiology , medicine , in vivo , receptor , pharmacology , biology , anesthesia , genetics
Although in vitro studies have identified numerous possible targets, the molecules that mediate the in vivo effects of volatile anesthetics remain largely unknown. The mammalian ryanodine receptor (Ryr) is a known halothane target, and the authors hypothesized that it has a central role in anesthesia.
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