Open AccessAssociation between Endothelial Dysfunction and Acute Brain Dysfunction during Critical Illness
Author(s) -
Christopher G. Hughes,
Alessandro Morandi,
Timothy D. Girard,
Bernhard Riedel,
Jennifer L. Thompson,
Ayumi Shintani,
Brenda T. Pun,
E. Wesley Ely,
Pratik P. Pandharipande
Publication year - 2012
Publication title -
anesthesiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.874
H-Index - 234
eISSN - 1528-1175
pISSN - 0003-3022
DOI - 10.1097/aln.0b013e31827bd193
Subject(s) - medicine , delirium , reactive hyperemia , intensive care unit , glasgow coma scale , endothelial dysfunction , coma (optics) , intensive care , prospective cohort study , executive dysfunction , severity of illness , systemic inflammation , anesthesia , organ dysfunction , sepsis , cardiology , intensive care medicine , blood flow , inflammation , psychiatry , neuropsychology , optics , cognition , physics
Acute brain dysfunction (delirium and coma) during critical illness is prevalent and costly, but the pathophysiology remains unclear. The relationship of acute brain dysfunction with endothelial function, which is impaired in critical illness and may contribute to alterations in cerebral blood flow and blood-brain barrier permeability, has not been studied. This study sought to determine whether systemic endothelial dysfunction is associated with acute brain dysfunction during critical illness.
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