Open AccessSelective 5-HT1A-R-agonist Repinotan Prevents Remifentanil-induced Ventilatory Depression and Prolongs Antinociception
Author(s) -
Ulf Guenther,
Nils Theuerkauf,
Daniel M. Huse,
Michael Böettcher,
Georg Wensing,
Christian Putensen,
Andreas Hoeft
Publication year - 2011
Publication title -
anesthesiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.874
H-Index - 234
eISSN - 1528-1175
pISSN - 0003-3022
DOI - 10.1097/aln.0b013e31823d08fa
Subject(s) - remifentanil , medicine , anesthesia , ventilation (architecture) , nociception , agonist , reflex , opioid , receptor , mechanical engineering , propofol , engineering
5-HT(1A)-R-agonist repinotan was shown to counteract a morphine-induced ventilatory depression but had pronociceptive effects at small doses (0.2 μg/kg). It remained to be clarified (1) whether a moderate dose of repinotan, sufficient to stimulate spontaneous breathing, impairs antinociception if plasma concentration decreases over time, and if (2) moderate doses prevent ventilatory depression if given before the opioid.
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