Open AccessCalcium Signaling in Intact Dorsal Root Ganglia
Author(s) -
Geza Gemes,
Marcel Rigaud,
Andrew S. Koopmeiners,
Mark Poroli,
Vasiliki Zoga,
Quinn H. Hogan
Publication year - 2010
Publication title -
anesthesiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.874
H-Index - 234
eISSN - 1528-1175
pISSN - 0003-3022
DOI - 10.1097/aln.0b013e3181e0ef3f
Subject(s) - stimulation , neuroscience , dorsal root ganglion , neuron , electrophysiology , local field potential , biophysics , neuromodulation , calcium imaging , calcium , sensory system , medicine , biology
Ca is the dominant second messenger in primary sensory neurons. In addition, disrupted Ca signaling is a prominent feature in pain models involving peripheral nerve injury. Standard cytoplasmic Ca recording techniques use high K or field stimulation and dissociated neurons. To compare findings in intact dorsal root ganglia, we used a method of simultaneous electrophysiologic and microfluorimetric recording.
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