Open AccessResuscitation with Lipid versus Epinephrine in a Rat Model of Bupivacaine Overdose
Author(s) -
Guy Weinberg,
Guido Di Gregorio,
Richard Ripper,
Kemba Kelly,
Malek G. Massad,
Lucas B. Edelman,
David E. Schwartz,
Nirali Shah,
Sophie Zheng,
Douglas L. Feinstein
Publication year - 2008
Publication title -
anesthesiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.874
H-Index - 234
eISSN - 1528-1175
pISSN - 0003-3022
DOI - 10.1097/aln.0b013e31816d91d2
Subject(s) - medicine , epinephrine , bupivacaine , resuscitation , anesthesia , medical emergency
Lipid emulsion infusion reverses cardiovascular compromise due to local anesthetic overdose in laboratory and clinical settings. The authors compared resuscitation with lipid, epinephrine, and saline control in a rat model of bupivacaine-induced cardiac toxicity to determine whether lipid provides a benefit over epinephrine.
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