Open AccessAutologous Transplantation of Endothelial Progenitor Cells Attenuates Acute Lung Injury in Rabbits
Author(s) -
Chen-Fuh Lam,
YenChin Liu,
Jen-Kuo Hsu,
Pei-An Yeh,
Ting-Ya Su,
Chien-Chi Huang,
MingWei Lin,
Ping-Ching Wu,
Pei-Jung Chang,
YuChuan Tsai
Publication year - 2008
Publication title -
anesthesiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.874
H-Index - 234
eISSN - 1528-1175
pISSN - 0003-3022
DOI - 10.1097/aln.0b013e318164ca64
Subject(s) - medicine , ards , transplantation , progenitor cell , lung , endothelium , lung transplantation , pulmonary artery , pathology , stem cell , cardiology , biology , genetics
Acute lung injury (ALI) and end-stage acute respiratory distress syndrome (ARDS) are among the most common causes of death in intensive care units. Activation and damage of pulmonary endothelium is the hallmark of ALI/ARDS. Recent studies have demonstrated the importance of circulating endothelial progenitor cells (EPCs) in maintaining normal endothelial function as well as endothelial repairing after vascular injury. Here, the authors present the first study demonstrating the therapeutic potential of EPCs in a rabbit model of ALI/ARDS.
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