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It is believed that the effectiveness of colloids as plasma volume expanders is dependent on the endothelial permeability for macromolecules. The objective of this study was to test the hypothesis that the plasma volume expanding effect of 5% albumin relative to that of a crystalloid solution is reduced if microvascular permeability is increased.

Plasma Volume Expansion with 5% Albumin Compared to Ringer’s Acetate during Normal and Increased Microvascular Permeability in the Rat