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The authors tested the hypothesis that the oxygen content of brain tissue is negligible by injecting an intracarotid bolus of  15 O-labeled tracer into rats. Under the hypothesis, the clearance rates of  15 O radioactivity from the brain after injections of both  15 O-labeled water (H 2  15 O) and  15 O-labeled oxyhemoglobin (HbO 15 O) should be identical. However, the logarithmic slope of the  15 O radioactivity curve after HbO 15 O injection (0.494 ± 0.071 min -1 ) was steeper than that after H 2  15 O injection (0.406 ± 0.038 min −1 ) ( P&lt;0.001, n = 13), where the time range used in the comparison was between 60 and 120 seconds after the injection. A possible interpretation of this result is that nonmetabolized O 15 O may dwell in the brain tissue for a finite period of time before it is eventually metabolized or returned to the blood stream unaltered. These findings contradict assumptions made by models currently used to measure cerebral oxygen metabolism.

journal of cerebral blood flow and metabolism

15O Radioactivity Clearance is Faster after Intracarotid Bolus Injection of 15O-Labeled Oxyhemoglobin than after 15O-Water Injection