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AND OBJECTIVES: While the impacts of age and testosterone on sexual function have been well-studied, the additive relationship of these three variables has seldom been mentioned. In the present study, we seek to assess the impact of testosterone and age on baseline sexual function in men with prostate cancer. METHODS: We retrospectively reviewed 850 patients who presented for primary treatment of prostate cancer between December 2009 and June 2018. Preoperative sexual function was measured via the International Index of Erectile Function-5 (IIEF-5). Total and free testosterone (FT and TT) were collected and calculated preoperatively in 822 patients. To assess the impact of age, patients were stratified patients by decade of life and the most predictive cut-off was determined to be at 60 years of age. Univariate and multivariate analyses were conducted to assess impact of FT, TT, age, Body Mass Index (BMI), and pathological grade on sexual function. RESULTS: Overall, 822 patients were included, of which 35.4% (291/822) were <60 years. Mean FT was significantly higher in the <60 aged cohort (6.74±4.24 ng/dL) vs. the >60 aged cohort (5.6±2.52 ng/dL), (p<0.001). In multivariate analysis, FT was only an independent predictor of IIEF-5 scores for patients >60 years old (p=0.018), but not in patients younger than 60 (p=0.69). Similarly, BMI was not significantly correlated with sexual function in younger men (<60 years old) (p>0.05), but was an independent predictor in the older cohort (p<0.001). Age was an independent predictor of sexual function in both cohorts (p=0.001 for <60; p<0.001 for >60). CONCLUSIONS: Our results show that lower FT levels do not impact IIEF-5 scores in patients <60 years old, but have a negative effect on IIEF-5 scores in patient >60 years old. In this group, that effect worsens with age. A FT level should be obtained in all patients over the age of 60 undergoing radical prostatectomy to assess postoperative sexual function recovery. Figure. No caption available. Figure. No caption available. Source of Funding: None

MP40-07 THE PREDICTIVE EFFECT OF FREE TESTOSTERONE ON SEXUAL FUNCTION INCREASES WITH AGE