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A critical early step in the establishment of Escherichia coli pyelonephritis is bacterial attachment via the tip protein of P fimbriae. This adhesin, PapG, binds to glycolipid receptors present on vaginal and kidney epithelial surfaces. In this study we investigated the efficacy of vaccination with purified PapDG protein complex in preventing pyelonephritis caused by E. coli.

ANTIBODY RESPONSES AND PROTECTION FROM PYELONEPHRITIS FOLLOWING VACCINATION WITH PURIFIED ESCHERICHIA COLI PAPDG PROTEIN