English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

The established phase of human essential hypertension is characterized by a normal cardiac output and an elevation in peripheral resistance. A considerable part of this increase in vascular resistance is determined by the structure of the microvasculature, in particular the small arteries and precapillary arterioles, where increases in the wall thickness : lumen ratios are frequently observed [1]. In addition, other abnormalities in the microvasculature are also known to occur, such as a reduction in microvessels. Rarefaction of capillaries and arterioles has been reported in many animal models of hypertension [2,3], and may also be involved in increasing peripheral resistance in essential hypertension [4]. Rarefaction of capillaries is caused by an absence of capillaries or a functional rarefaction, in which the capillaries are present but not perfused. Capillary rarefaction has not only been reported in established essential hypertension [4], but also in borderline essential hypertension [5] and young adults with a predisposition to high blood pressure [6]. This latter observation suggests that defective angiogenesis/ arteriogenesis may be an etiological component in the inheritance of high blood pressure, and raises the possibility that genetic factors may be responsible for at least a component of microvascular rarefaction.

The structural basis of hypertension: vascular remodelling, rarefaction and angiogenesis/arteriogenesis