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Despite extensive research efforts, no therapeutic agents are currently clinically indicated for the treatment of peripheral nerve injuries. Insulin-like growth factor 1 (IGF-1) is an ideal therapeutic candidate because it can accelerate axonal regeneration and also minimize the deleterious effects of prolonged denervation on muscle and Schwann cells. However, given its short half-life, a practical delivery system is needed to stabilize the protein and provide sustained release to target tissues. Using a novel encapsulation method, we demonstrated sustained release of bioactive IGF-1 from nanoparticles, in vitro, and improved nerve regeneration and functional recovery, in vivo. An optimized carrier system to maintain the nanoparticles at target tissue sites for the duration of drug release and avoid frequent redosing is now needed. We, therefore, developed a biocompatible nanofiber hydrogel composite that could be loaded with IGF-1 nanoparticles; fine-tuned its drug release kinetics in vitro and in vivo; and applied it in a chronic denervation median nerve model to assess its impact on functional recovery.

plastic and reconstructive surgery. global open

Self-propagating Autologous Skin Substrate for the Treatment of Cutaneous Defects: Clinical Series of the Utilization of a Novel Therapy for In Vivo Full-thickness Skin Regeneration