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RESULTS: The present series of novel co-culture systems reveal that ASCs do not migrate faster towards a benign cancer (MCF-7) when compared synchronously to fibroblasts. Conversely, in a model with aggressive breast cancer cells (MDA-MB-231), ASCs are seen to have a highly pronounced tropism to the malignant cancer population which remains static. Simultaneously, in the same model, cancer cells exhibit significant migration towards a static fibroblast population (p< 0.05). The attraction of ASCs to MDA-MB-231 cells is dose dependent, showing higher migration for higher breast cancer cell numbers.

Abstract QS18: Neural Signal Transduction with the Muscle Cuff Regenerative Peripheral Nerve Interface