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PURPOSE: Current microsurgical techniques do not address the atrophy and loss of Schwann cells (SCs) after peripheral nerve trauma. SCs are the principal glial cells that are known to facilitate axonal regeneration through cytokine signaling and spatial cues for directed axonal sprouting. To enhance peripheral nerve regeneration, SC replacement therapies using mesenchymal stem cells transformed into SC-like phenotypes have been investigated, but a robust source of mesenchymal stem cells is yet to be identified. Our lab has previously demonstrated that muscle-derived stem cells (MDSCs) induced to express SC-like phenotypes reduce denervation muscle atrophy, improve neuromuscular re-innervation, and restore muscle function after upper extremity nerve trauma in rodents, given their myelination capabilities in vivo. This study further characterizes these MDSC-derived SC-like cells and confirms the myelination capacity of the SC-like cells through molecular and genetic profiling.

Abstract 129: Molecular and Genetic Characterization of Functional Schwann-Cell Like Cells (iMDSCs) Transformed from Muscle Derived Stem Cells