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BACKGROUND: There is a clinical need for an off-theshelf bioinductive soft-tissue replacement in reconstructive surgery. Our group developed injectable Allograft Adipose Matrix (AAM) as a solution, derived from cadaveric human subcutaneous adipose tissue through a decellularization and milling process. The final form is lyophilized powder rehydrated before use. The aim was to demonstrate the translational development of AAM from conception to clinical study.

Abstract: Development of Injectable Allograft Adipose Matrix for Soft Tissue Filling: From Conception to Clinical Trial